Prioritize gear that offers resistances, and be sure to keep a look out for charms of the same nature. That means in the endgame you'll need somewhere around +175 to all resistances to have maximum protection. You'll see a -40 penalty in Nightmare, and a -100 penalty in Hell. If you have, say, 15 poison resistance, your character will see a 15% reduction from any poison elemental attack.ĭon't get too comfortable with resistances in Normal difficulty, as the base numbers take a deep dive once you hit the harder difficulties. You can check your resistances on the main character screen, just below your stats. For the latter, be sure to rescue Anya in Act Five. Characters start Normal difficulty with no resistances, but they can be gained through equipment and certain quests. Your character's resistances to Fire, Cold, Lightning, and Poison are what will keep you alive when you move into Nightmare and Hell difficulties. Source: Windows Central (Image credit: Source: Windows Central)